Original Research Paper

Immunoexpression of p16 and ki67 markers in Oral squamous cell carcinoma-A study of 56 cases

  Abstract :

Background: Oral squamous cell carcinoma (OSCC), is the third most common form of cancer in the developing countries and sixth most common cancer in the world. Oral carcinogenesis is a multistage process arising from the accumulation of genetic events that disturb cell cycle control, proliferation, motility, survival and tumour-related angiogenesis. Hyper methylated p16 promoter tend to transform into oral cancers. Ki67 is a monoclonal marker and exclusively related to proliferation of cells and aggressiveness of malignant tumours. In this study, we evaluated the expression of p16, and Ki67 in different oral squamous cell carcinoma. Material and method: Prospective study was conducted on total of 56 oral biopsy received in the Department of Pathology, Indira Gandhi Institute of Medical Sciences, Patna. Inclusion criteria include patient above 18 years of age and oral biopsy received with a clinical suspicion of Oral squamous cell carcinoma.Result: We found that 46 cases (82.1%) was seen in male. Out of 56 cases, 22 cases (27.5%) were well differentiated, 31 cases (38.7%) were moderately differentiated and 3 cases (3.8%) were found to be poorly differentiated Oral squamous cell carcinoma. p16 was negative in 24 cases (42.9%) and positive in 32 cases (57.1%). Expression of p16 was increases with increasing tumor grade. Ki67 was positive in all cases and its expression increases with increasing tumor grade. Conclusion:The expression of cell cycle proteins p16 and proliferative marker Ki67 represents the significant marker to detect early oral and evaluate tumor grade of oral squamous cell carcinoma. These markers also help in deciding treatment protocol and prognostic assessment.

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