Original Research Paper
Role Of Bacteriophages In Targeting Antibiotic-Resistant Bacteria
The rise of antibiotic-resistant bacteria poses a significant challenge to global health, necessitating innovative approaches to combat these infections. Bacteriophages, viruses that specifically infect bacteria, have emerged as promising alternatives to traditional antibiotics. This review explores the use of bacteriophages as a targeted therapy to tackle antibiotic-resistant bacteria. Bacteriophages offer several advantages, including their specificity for bacterial targets, ability to evolve and adapt to bacterial resistance mechanisms, and potential for personalized treatment. The mechanisms of phage action, including direct lysis of bacteria and modulation of the host immune response, are discussed. Moreover, strategies to enhance the effectiveness of phage therapy, such as phage cocktails and phage engineering, are explored. Challenges and considerations, including safety, regulatory aspects, and bacterial resistance to phages, are also examined. Despite these challenges, bacteriophages hold tremendous potential as a valuable tool in the fight against antibiotic-resistant bacteria, offering hope for more targeted and effective treatments in the future.
bacteriophages antibiotic resistance bacterial infections targeted therapy phage therapy personalized treatment mechanisms of action phage cocktails phage engineering safety regulatory aspects bacterial resistance innovative approaches global health.
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