A STYUDY ON THE BACTERIOLOGICAL PROFILE OF URINARY TRACT INFECTION AND ANTIBIOTICS SENSITIVITY PATTERN IN A TERTIARY CARE HOSPITAL, JAMNAGAR, GUJARAT (INDIA).
Urinary tract infection (UTI) is defined as a disease caused by microbial invasion of the urinary tract that extends from the renal cortex of kidney to the urethral meatus. Urinary tract infections (UTIs) are among most common bacterial infections that need medical care; accounting for second most common infection after respiratory tract infections in community. Whereas in hospitals, they are the most common hospital acquired infections (HAIs) accounting for 35% of total HAIs. Approximately 1 in 3 women will require antimicrobial treatment for a Urinary Tract Infection (UTI) before age 24, and 50% of women will have a UTI during their lifetime. Escherichia coli are the most common cause of UTIs. Clean-Catch midstream urine was collected of the patients with history of fever, abdominal pain, dysuria, urgency and frequency. During study 343 urine samples received in microbiology laboratory for culture were processed according to standard protocol. Isolates were identified by conventional phenotypic methods and antibiotic sensitivity determined by standard Kirby Bauer disc diffusion method and follow Clinical and Laboratory Standards Institute (CLSI) guidelines. In this study 86 (25.07%) patients out of 343 were shown to be urine culture positive out of them 54 (62.79%) females and 32 (37.21%) males. The most isolated bacterium was E. coli with frequency rate of 54 (62.79%). The other bacteria were Klebsiella spp. 20(23.26%), Pseudomonas spp. 07 (8.14%), and other gram negative bacteria 05 (5.81%). It is concluded that Gram-negative bacilli were responsible for UTI infections in our patients. The most common isolated bacteria from urinary tract infections were E. coli followed by Klebsiella pneumoniae. The most effective antimicrobial agents were Imipenem and Piperacillin-tazobactam and the least effective one was cephalexin.
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