Research Paper

Histopathological study of different forms of Psoriasis and their clinical correction

  Abstract :

Background Psoriasis (Gk. psora, the itch) is a chronic papulosquamous disease of unknown aetiology with unpredictable course of remission andexacerbation. Because the clinical presentation of psoriasis is varied, many times the definitive diagnosis depends on the histological examination. However both genetic and environmental factors are thought to play a role in initiation and progression of disease.ObjectiveTo correlate Clinical and Histological features of Psoriasis.Material and MethodsA total of 110 cases were studied. Clinical study will be done in Department of Dermatology, S. N. Medical College.Histopathological study of Skin Biopsy specimens will be done in Department of Pathology, S.N. Medical College. H & E Stained slides were studied of the cases studied.Following Histological Features were studied.ParakeratosisHyperkeratosisAgranulosisHypergranulosisHypogranulosisSuprapapillary ThinningElongation of Rete RidgesMicro-munro AbscessKogoj AbscessDemal Lymphocytic InfiltratedDilated Blood VesselsResultsAmong 110 cases studied, 91 cases were of Chronic Plaque Psoriasis, 9 Cases were of Guttate Psoriais, 2 cases were of Inverse Psoriais, 3 cases of Erythrodermic Psoriasis, 3 cases of Generalized Pustular Psoriasis and 2 cases of Palmo-plantar Psoriasis.Parkeratosis, Hyperkeratosis, Hyogranulosis, Micro-Munro Abscess, Dermal Lymphocytic Infiltrate and Dilated Blood Vessels were prominent Histological findings in this study.ConclusionThe present study validates that after using combination of varied clinical features and varied histological findings in suspected cases of Psoriasis, we can arrive at the definitive diagnosis of Psoriasis.

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