Research Paper

Ki-67 Proliferation Index and Progesterone Receptor status in different histological subtypes and grades of meningioma at a tertiary care institute in north western India

  Abstract :

Context: Meningiomas are the most common benign brain tumors. WHO grading system divides these tumours into three grades on the basis of histology. Some of the diagnostic histologic criterias for grading are vague and difficult to interpret. Few studies have reported expression of both Ki- 67 proliferative index and Progesterome receptor in different grades and histological subtypes of meningioma.Aims: To assess the expression of Ki-67 and progesterone receptor(PR)in different histological types and grades of meningiomas.Settings and Design: Hospital based retrospective studyMethods and Material: A total of 100 consecutive cases were collected over a period of one year. Haematoxylin and Eosin staining was done for histological typing and grading of tumors. Immonohistochemical staining was done for Ki-67 and PR and Ki-67 labelling index(LI) and PR score was calculated.Statistical analysis used: Chi- Square test.Results: Mean Ki-67 LI showed an increase with increasing grades of meningioma. The difference in mean Ki-67 LI between Grade I and II was statistically significant. PR positivity was significantly higher in females versus males, in Grade I versus Grade II and in Grade I versus Grade III meningiomas. Moreover mean Ki-67 LI was significantly higher in PR negative versus PR positive meningiomas.Conclusions: Evaluation of PR and Ki-67 LI along with conventional histologic evaluation can be useful to delineate aggressive cases from benign and in distinguishing between grades of meningioma especially in borderline cases when histology is difficult.

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