Research Paper

Clear cell SCC: Uncommon variant of common malignancy in head and neck

Dr. Kakoti Lopa M, Dr. Mahanta Debanwita, Dr. Choudhury Zachariya, Dr. Sharma Jagannath D

  Abstract :

Clear cell squamous cell carcinoma (SCC) is an extremely rare and incompletely understood entity. Clear cells change occurs due to cytoplasmic accumulation of glycogen, water, intermediate filaments, immature zymogen granules, or a paucity of cellular organelles. We, hereby present a case of clear cell variant of squamous carcinoma on lower gingivo buccal mucosa in 59-year-old male patient. Histopathology showed sheets of clear cell separated by fibrous septa and foci showing squamous cells with malignant features. Histochemical findings showed Periodic Acid-Schiff (PAS) negative and immunohistochemistry (IHC) revealed CK positivity. We concluded by emphasizing on the need of further analysis of all clear cell tumours in head and neck with histochemistry and IHC investigations to arrive at the proper diagnosis. To establish the biological nature, significance and clinical course of clear cell SCC more number of case reports are expected to be published in future.

  Cite This Article:

CLEAR CELL SCC: UNCOMMON VARIANT OF COMMON MALIGNANCY IN HEAD AND NECK, Dr. Kakoti Lopa M, Dr. Mahanta Debanwita, Dr. Choudhury Zachariya, Dr. Sharma Jagannath D, INTERNATIONAL JOURNAL OF RESEARCH IN PATHOLOGY AND MICROBIOLOGY : Volume-3 | Issue-1 | January-2019

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