Research Paper

UTILITY OF Ki67 IN PRE-MALIGNANT AND MALIGNANT SKIN LESIONS

  Abstract :

Objective: The purpose of the study is to evaluate the significance of ki67 antigen expression in premalignant and malignant skin lesions. Materials and methods: This was a retrospective study that included 12 premalignant and 15 malignant skin lesions diagnosed during June 2016 to May 2018. Immunohistochemistry with ki67 was done on these 27 cases. The ki67 proliferative index was determined by counting stained nuclei among 500 tumor cells. Result: The Ki67 labeling index for keratoacanthoma was 33%, Bowen's disease was 37%, Bowen's disease with microinvasion was 40.8%, Squamous cell carcinoma was 42.2%, Basal cell carcinoma was 53%.Conclusion: IHC with Ki67 may be suggested in punch biopsies of skin in suspected malignancies to know the aggressive nature of the lesion.

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