Original Research Paper

Serum adiponectin in Gestational diabetes mellitus.

  Abstract :

Introduction:Gestational diabetes mellitus (GDM) is associated with a state of decreased insulin sensitivity along with increased body mass index. It has been studied that serum adiponectin produced by human placenta and adipose tissue has profound insulin sensitizing properties along with anti-inflammatory and anti-atherogenic effects. A decreased level of serum adiponectin is an independent risk factor for future development of diabetes. Conversely, increased level of serum adiponectin reduces the chances of Type 2 DM. Aims & Objectives:To study the association of serum adiponectin levels with GDM.Materials & method:Thirty pregnant women between 24th to 28th weeks of pregnancy with GDM and no other co-morbidities and thirty age-matched healthy control pregnant women without GDM were included in the study, presenting in the out-patient department of the hospital over a period of one year and fulfilling the inclusion criteria.Result:The data shows that the GDM group have a higher pre-pregnancy BMI, lipid profile and HbA1c levels as compared to those with normal pregnant women and a lower serum adiponectin level. A significant inverse correlation was seen between serum adiponectin and blood glucose levels at GCT and OGTT, HbA1c, BMI and lipid profile. Also, HbA1c level shows a positive correlation with GCT, BMI and serum cholesterol. Conclusion:Gestational Diabetes mellitus is significantly associated with associated with low levels of serum adiponectin.

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