Original Research Paper

Correlation of drug resistance pattern with Lipase Production in clinical isolates of Klebsiella pneumoniae

  Abstract :

Aim: The aim of our study is to correlate drug resistance pattern with Lipase production. Materials and Methods:Total of 150 clinical isolates of Klebsiella pneumoniae from various clinical samples have been collected during July 2020 December 2020. Lipase test have been detected by standard technique. And antibiotic susceptibility test has been performed by using Kirby-Bauer disk diffusion method as per CLSI guidelines [8]. ESBL test was detected by combined disc diffusion method and Carbapenemase production was detected by using E-test strip method as per CLSI guidelines.Results and Discussion: In 150 consecutive non-duplicate isolates, 74 isolates from Exudate, 7 isolates from Blood and 69 isolates from urine. From those 85(56.6%) isolates produced Lipase production. The number of isolates in ESBL producer were 43(57.3%). In our study, 20(32.25%) isolates produce Carbapenemase production.Lipase Production: Phospholipases are a diverse group of lipolytic enzymes utilized by a variety of bacterial pathogens. During the infection process to support the establishment of a replicative niche. It has been shown that hydrolysis of host membranes through the action of the bacterial phospholipases is correlated with extensive host cell destruction. [5].

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