Original Research Paper
A Study Of Prognostic Role Of Neutrophil To Lymphocyte Ratio In Covid-19 Patients In A Tertiary Care Hospital
INTRODUCTION Coronavirus disease 2019 (COVID-19) is highly contagious, continues to spread rapidly and causes serious harm. Circulating biomarkers that can evaluate inflammation and immune status, and can be potentially useful in diagnosis and prognosis of COVID-19 patients. In present study , we assessed the potential of the neutrophil to lymphocyte ratio (NLR) as an indicator of severity severe versus nonsevere COVID-19 cases.Methods: It was a retrospective observational study .Age, gender, TLC, ANC, ALC and neutrophil-to-lymphocyte ratio (NLR) of 80 patients with laboratory confirmed COVID-19 were investigated and compared. Suitable statistics were applied to compare the data.Results: we analyzed 80 covid 19 positive patients, which included 40 patients with COVID-19 and ICU admission and 40 patients with COVID-19 and admission in isolation ward or covid care centre. Maximum number of patients were male (68.8%). Mean age of study group was 52.12 year. Median TLC (Total Leukocyte Count)of study group was 8200, median ANC (Absolute Neutrophil Count ) was 6479, median ALC (Absolute Lymphocyte Count) was 1282 and Median NLR (Neutrophil to Lymphocyte ratio) was 4.45. We found statistically significant association between age and severity of Covid-19 disease, gender was not significantly associated with the severity of the Covid -19 disease. TLC, ANC, ALC and NLR was found to be significantly associated with the severity of the Covid-19 disease.Conclusions: Elevated age and NLR can be considered independent biomarkers for indicating poor clinical outcomes in patients with COVID -19.
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