Research Paper

ESTIMATION OF PLASMA LIPIDS IN DIFFERENT HISTOPATHOLOGICAL GRADES OF ORAL SQUAMOUS CELL CARCINOMA

  Abstract :

Background: Lipids play a major key role in maintenance of cell integrity. Since years there have been discussions about the correlation of alterations of the lipid profile and various cancers. Alterations in the lipid profile are associated with the oral cancer and oral precancer. Incidence of oral squamous cell carcinoma (OSCC) cancer has been reported to be more in patients with reduced lipid profiles. This study was done to evaluate the variation of plasma lipids in different histopathological grades of oral squamous cell carcinoma and to estimate the correlation of the altered lipid profile with tumor differentiation. Methodology: Blood samples from 30 oral squamous cell carcinoma patients (10 well differentiated, 10 moderately differentiated, 10 poorly differentiated) were subjected to lipid analysis. The lipid analysis was a panel of tests consisting of five main parameters; Total Cholesterol (TC), Triglycerides (TG), High Density Lipoproteins (HDLs), Low Density Lipoprotein( LDLs), and Very Low Density Lipoprotein (VLDLs). The results obtained were compared with the lipid profile of control group (n=10). ANOVA test was done for correlating the lipid values.Result & conclusion: The results of ANOVA have shown significant values of TC, HDL and LDL with a p value of 0.000, 0.000, 0.001 respectively. Hence Post Hoc Analysis was done to correlate among the control group, study group and various histopathological grades of oral squamous cell carcinoma. The results have shown no correlation among the grades of oral squamous cell carcinoma. Among the control group and oral cancer group the results were statistically significant. The p values of TG and VLDL were not significant with a value of 0.067 and 0.289 respectively. Since the results were not significant Post Hoc analysis was not done for the correlation. Overall, the results revealed that there is no significance in the variation of lipid levels between the histopathological grades of oral squamous cell carcinoma.

  Cite This Article:

  References:

  Article: