RARE SEQUELAE OF HASHIMOTO THYROIDITIS: TWO CASE REPORTS OF MEDULLARY CARCINOMA AND POORLY DIFFERENTIATED CARCINOMA OF THYROID WITH HASHIMOTO THYROIDITIS.
Hashimoto thyroiditis (HT) is an autoimmune disease that leads to the destruction of thyroid gland with gradual and progressive hypothyroidism. Individuals suffering from Hashimoto thyroiditis are at an increased risk of developing different thyroid neoplasms. Most common being papillary carcinoma of thyroid, followed by extranodal marginal zone B-cell lymphoma of thyroid and Hurthle cell neoplasms. Incidence of medullary carcinoma (MC) and poorly differentiated thyroid carcinoma (PDTC) of thyroid, coexisting with Hashimoto thyroiditis are rare. According to international literature incidence of MC accounts for only 0.35% of all malignant neoplasms developing in a patient of HT. Whereas no formal statistics are available regarding the incidence of PDTC in patients with HT, which further accentuates the rarity of this unusual combination. Here we present two such rare case report of patients with histopathological features of MC and PDTC coexisting with long standing Hashimoto thyroiditis.
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