Research Paper

Biochemical indicators for the early diagnosis of severe dengue fever: An Indian Study

Kamlesh Kumar Singh, Khushi Ram Rathi, Satish Mendonca, Pooja Gupta, Devika Gupta

  Abstract :

BackgroundDengue also known as breakbone fever is a viral infection which is one of the most important mosquito borne diseases of the Indian subcontinent. It has become a major public health problem. Spread of the disease has lead to the recognition of atypical manifestations apart from the classical clinical features of dengue infection.AimTo determine the biochemical indicators for the early diagnosis of severe dengue fever.MethodsA cross sectional study of dengue patients admitted as well as reporting to Medical OPD with confirmed infection with dengue virus was conducted in the year 2014 during the monsoon and post monsoon seasons. Patients with serological confirmation of dengue infection were classified according to the World Health Organization 2009 definitions of dengue fever without warning signs (DF) and dengue fever with warning signs or severe dengue (SD). All patients were evaluated prospectively for the first twelve days of the disease to determine their clinical and biochemical parameters. We evaluated the biochemical parameters as predictors of severe dengue fever (SD).ResultsOut of the 398 patients, 60 developed severe dengue fever (SD). Patients with severe dengue fever had higher levels of lactate dehydrogenase (LDH), creatine kinase (CK), blood glucose and aspartate aminotransferase, and lower levels of albumin, total cholesterol, triglycerides and calcium. Multivariate analysis showed that early alterations of CK (hazard ratio [HR] =6.98, 95% confidence interval [CI] = 2.34-20.85, P =0.001), LDH (hazard ratio [HR] =3.19, 95% confidence interval [CI] = 1.01-10.12, P

  Cite This Article:

BIOCHEMICAL INDICATORS FOR THE EARLY DIAGNOSIS OF SEVERE DENGUE FEVER: AN INDIAN STUDY, Kamlesh Kumar Singh, Khushi Ram Rathi, Satish Mendonca, Pooja Gupta, Devika Gupta, INTERNATIONAL JOURNAL OF RESEARCH IN PATHOLOGY AND MICROBIOLOGY : Volume-2 | Issue-4 | October-2018

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